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Updated: Apr 17, 2026
Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
Published on: January 28, 2019
Inactivated human rotavirus vaccine induces heterotypic antibody response: correction and development of IgG avidity
Daniel E Velasquez1, Yuhuan Wang, Baoming Jiang
1a Division of Viral Diseases ; Centers for Disease Control and Prevention ; Atlanta , GA USA.
Abstract:
To improve lower efficacy among infants in low income countries and the safety (e.g., rare but severe intussusception) of live oral rotavirus vaccines, we have developed CDC-9 strain with G1P[8] specificity as a candidate inactivated rotavirus vaccine (IRV). This IRV of 3 doses elicits high titers of IgG, neutralizing activity to homotypic and heterotypic human strains and IgG avidity in guinea pigs, thus is a promising alternative to enhance global immunization against rotavirus in children.
