Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bromocriptine-induced hypothermia: D-2 receptor involvement.

M R Zarrindast1, M Mahmoudi

  • 1Department of Pharmacology, Medical Faculty, University of Tehran, Iran.

Archives Internationales De Pharmacodynamie Et De Therapie
|March 1, 1989
PubMed
Summary

Bromocriptine causes a dose-dependent drop in mouse body temperature. This hypothermic effect is linked to D-2 dopamine receptors, as indicated by experiments involving specific blocking agents and neurotransmitter depletors.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

STSM 2025 & 2nd African Medical Writing Congress.

La Tunisie medicale·2026
Same author

Unveiling the hidden aggression: a rare case of uterine leiomyosarcoma and its diagnostic dilemmas.

Annals of medicine and surgery (2012)·2025
Same author

2022 TUNISIAN NATIONAL CONGRESS OF MEDICINE ABSTRACTS.

La Tunisie medicale·2023
Same author

Clinical features and bleeding risk factors of angiodysplasia lesions in a Tunisian population.

Revista de gastroenterologia de Mexico (English)·2023
Same author

Predictive factors of difficult biliary cannulation: An experience of a tunisian tertiary center.

Heliyon·2023
Same author

Comparison of clinicodemographic characteristics and pattern of vascular involvement in 126 patients with Takayasu arteritis: a report from Iran and Turkey.

Reumatismo·2022

Area of Science:

  • Neuropharmacology
  • Physiology
  • Endocrinology

Background:

  • Bromocriptine is a dopamine receptor agonist.
  • Dopamine plays a role in thermoregulation.
  • The precise mechanism of bromocriptine's effect on body temperature is not fully understood.

Purpose of the Study:

  • To investigate the role of dopamine receptors in bromocriptine-induced hypothermia.
  • To determine the specific dopamine receptor subtype involved.

Main Methods:

  • Administered varying doses of bromocriptine (2-16 mg/kg, i.p.) to mice.
  • Pretreated mice with dopamine receptor antagonists (sulpiride, SCH 23390, methergoline) and other agents (phenoxybenzamine, propranolol, atropine).
  • Depleted catecholamine stores using reserpine plus alpha-methyl-p-tyrosine before bromocriptine administration.

Main Results:

  • Bromocriptine induced a dose-dependent decrease in core body temperature.
  • Sulpiride pretreatment significantly reduced the hypothermic effect.
  • SCH 23390, methergoline, phenoxybenzamine, propranolol, and atropine did not alter the hypothermia.
  • Reserpine plus alpha-methyl-p-tyrosine abolished the hypothermic response.

Conclusions:

  • D-2 dopamine receptors are implicated in the hypothermic effects of bromocriptine.
  • The findings suggest a specific role for D-2 dopamine receptor activation in thermoregulation.

Related Experiment Videos