Related Experiment Video

Updated: Apr 17, 2026

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

6.5K

Genetic basis for clinical response to CTLA-4 blockade

Alexandra Snyder, Jedd D Wolchok, Timothy A Chan

    The New England Journal of Medicine
    |February 19, 2015
    PubMed
    Summary

    No abstract available in PubMed .

    More Related Videos

    Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence
    10:29

    Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence

    Published on: August 14, 2019

    11.3K
    Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
    09:15

    Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

    Published on: February 24, 2023

    4.2K

    Related Experiment Videos

    Last Updated: Apr 17, 2026

    Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
    09:08

    Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

    Published on: October 14, 2021

    6.5K
    Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence
    10:29

    Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence

    Published on: August 14, 2019

    11.3K
    Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
    09:15

    Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

    Published on: February 24, 2023

    4.2K

    Related Concept Videos

    Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

    Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

    72
    Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
    72
    T Cell Activation and Clonal Selection01:22

    T Cell Activation and Clonal Selection

    17.9K
    T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
    Naive T cells that have not yet encountered an antigen express two primary CD...
    17.9K

    Articles linked to this work by shared authors, journal, and citation graph.

    Randomized, Double-Blind, Placebo-Controlled First-in-Human Trial of a First-in-Class AI-Designed Monoclonal Antibody (GB-0669) Against the Conserved SARS-CoV-2 Spike S2 Stem Helix.

    The Journal of infectious diseases·2026

    Pharmacologic LDH inhibition redirects intratumoral glucose uptake and improves antitumor immunity in solid tumor models.

    The Journal of clinical investigation·2024

    Biomarker development for PD-(L)1 axis inhibition: a consensus view from the SITC Biomarkers Committee.

    Journal for immunotherapy of cancer·2024

    Comparative study of immune response to local tumor destruction modalities in a murine breast cancer model.

    Frontiers in oncology·2024

    Durable complete response in a patient with leptomeningeal melanoma after treatment with dabrafenib, trametinib, and nivolumab.

    Pigment cell & melanoma research·2024

    Intermittent MEK Inhibition with GITR Costimulation Rescues T-cell Function for Increased Efficacy with CTLA-4 Blockade in Solid Tumor Models.

    Cancer immunology research·2024

    Evidence-Based Tobacco-Cessation Strategies for Low- and Middle-Income Countries.

    The New England journal of medicine·2026

    GATA1 knockdown enhances CD8+ T cell responses and protects against immune escape in cervical squamous cell carcinoma through FGL1 downregulation.

    Journal of molecular histology·2026

    Tolerability of [161Tb]Tb-SibuDAB in comparison to other PSMA-targeting radioligands in the preclinical setting.

    European journal of nuclear medicine and molecular imaging·2026

    Efficacy and safety of adjuvant CDK4/6 inhibitors in hormone receptor-positive, HER2-negative early breast cancer: Updated evidence from a systematic review and meta-analysis.

    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners·2026

    Decision-to-outcome analysis of multidisciplinary tumor board-managed NSCLC patients.

    Turk gogus kalp damar cerrahisi dergisi·2026

    Electronic Structure Engineering at C7 Position of Thieno-Cytosine (thC): Toward Optimal Probe-Adduct Interactions with ABPG in DNA.

    The journal of physical chemistry. B·2026

    How Functional Variants Reconfigure the Rac2 Conformational Landscape.

    The journal of physical chemistry. B·2026
    See all related articles
    JoVE
    x logofacebook logolinkedin logoyoutube logo
    ABOUT JoVE
    OverviewLeadershipBlogJoVE Help Center
    AUTHORS
    Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
    LIBRARIANS
    TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
    RESEARCH
    JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
    EDUCATION
    JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
    Terms & Conditions of Use
    Privacy Policy
    Policies
    Jove
    Visualize
    Contact Us