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Characterizing protein modifications by reactive metabolites using magnetic bead bioreactors and LC-MS/MS
Dandan Li1, You-Jun Fu, James F Rusling
1Department of Chemistry, University of Connecticut, Storrs, Connecticut 06269, USA. james.rusling@uconn.edu.
Chemical Communications (Cambridge, England)
|February 19, 2015
Abstract:
We report here label-free metabolite-protein adduct detection and identification employing magnetic beads coated with metabolic enzymes as bioreactors to generate metabolites and possible metabolite-protein adducts for analysis by liquid chromatography-tandem mass spectrometry.
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