Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

132
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
132
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

314
Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
314
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

144
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
144
Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

211
Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
211
Drug Delivery: Overview01:16

Drug Delivery: Overview

1.2K
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
1.2K
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

289
Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
289

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: Charge transfer in triphenylamine-tetrazine covalent organic frameworks for solar-driven hydrogen peroxide production.

Nature communications·2026
Same author

Probing the Acid-Induced Hydrolysis of Sucrose Monopalmitate and Its Role in Interfacial Properties.

Journal of agricultural and food chemistry·2026
Same author

Soy lecithin and ethyl lauroyl arginate mitigate pH sensitivity and oxidative degradation of sucrose monopalmitate-based emulsions.

Food chemistry·2026
Same author

Navigation and selection of spermatozoa in a radial flow microfluidic device.

Lab on a chip·2025
Same author

Charge transfer in triphenylamine-tetrazine covalent organic frameworks for solar-driven hydrogen peroxide production.

Nature communications·2025
Same author

Protecting phytase from food processing stress using acid-resistant core-shell hydrogel carriers.

Food research international (Ottawa, Ont.)·2025

Related Experiment Video

Updated: Apr 17, 2026

Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform
06:27

Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform

Published on: October 20, 2020

5.7K

Microcapsules for Enhanced Cargo Retention and Diversity.

Maximilian A Zieringer1, Nick J Carroll1, Alireza Abbaspourrad1

  • 1School of Engineering and Applied Sciences and Department of Physics, Harvard University, Cambridge, MA, 02138, USA.

Small (Weinheim an Der Bergstrasse, Germany)
|February 19, 2015
PubMed
Summary

New perfluoropolyether (PFPE) microcapsules prevent leakage of encapsulated materials. These microcapsules offer enhanced retention and controlled release for diverse applications in agriculture, drug delivery, and cosmetics.

Keywords:
encapsulationmicrocapsulesmicrofluidicsperfluoropolyethersretention

More Related Videos

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
10:16

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

8.2K
Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
09:34

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Published on: February 9, 2019

9.6K

Related Experiment Videos

Last Updated: Apr 17, 2026

Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform
06:27

Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform

Published on: October 20, 2020

5.7K
Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
10:16

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

8.2K
Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
09:34

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Published on: February 9, 2019

9.6K

Area of Science:

  • Materials Science
  • Chemical Engineering
  • Nanotechnology

Background:

  • Preventing premature leakage of encapsulated substances is crucial for microcapsule applications in agriculture, drug delivery, and cosmetics.
  • Current microcapsule technologies face challenges in retaining active ingredients before triggered release.

Purpose of the Study:

  • To develop perfluoropolyether (PFPE)-based microcapsules using a microfluidic approach for enhanced retention of encapsulated actives.
  • To demonstrate the cargo diversity and controlled release capabilities of these novel microcapsules.

Main Methods:

  • Fabrication of PFPE microcapsules with a high core-shell ratio via a microfluidic method.
  • Encapsulation of model compounds (Allura Red, CaCl2, hydrophobic substances) in either water-in-oil emulsion or organic solvent cores.
  • Incorporation of degradable silica particles into the PFPE shell to introduce porosity and functionality.

Main Results:

  • PFPE microcapsules exhibited less than 2% leakage of encapsulated model compounds over a four-week period.
  • Demonstrated cargo diversity with both aqueous and organic cores, enabling sustained release of hydrophobic compounds.
  • Incorporation of silica particles provided shell porosity and functionality without compromising retention.

Conclusions:

  • PFPE microcapsules with high core-shell ratios effectively retain diverse cargoes for extended durations.
  • The developed microcapsules are suitable for controlled release applications demanding minimal shell material residue.
  • This technology addresses a key challenge in microencapsulation, paving the way for advanced applications.