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Related Experiment Video

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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
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Microstructural white matter tissue characteristics are modulated by homocysteine: a diffusion tensor imaging study.

Jung-Lung Hsu1, Wei-Hung Chen2, Chyi-Huey Bai3

  • 1Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; Section of Dementia and Cognitive Impairment, Department of Neurology, Chang Gung Memorial Hospital, Linkou, Taiwan; Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands.

Plos One
|February 19, 2015
PubMed
Summary

Elevated homocysteine levels correlate with microstructural brain changes in healthy individuals. Diffusion Tensor Imaging (DTI) reveals these subtle white matter (WM) alterations, even in the absence of overt disease.

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Area of Science:

  • Neuroscience
  • Radiology
  • Biochemistry

Background:

  • Elevated homocysteine is linked to brain white matter (WM) damage via endothelial dysfunction, inflammation, and neurotoxicity.
  • Previous studies noted associations between high homocysteine and macroscopic brain changes, but microstructural effects in healthy subjects remained unclear.

Purpose of the Study:

  • To investigate the relationship between homocysteine levels and microstructural brain tissue properties in healthy individuals.
  • To determine if Diffusion Tensor Imaging (DTI) can detect subtle WM changes related to homocysteine in a healthy cohort.

Main Methods:

  • A cohort of 338 healthy participants was analyzed.
  • Microstructural brain measures were computed using Diffusion Tensor Imaging (DTI).
  • Correlations between homocysteine levels and DTI-derived microstructural measures were assessed.

Main Results:

  • Significant positive correlations were found between homocysteine levels and diffusivity measures.
  • These correlations were observed in the bilateral temporal WM, brainstem, and bilateral cerebellar peduncle.
  • This study demonstrates DTI's sensitivity to microstructural WM changes associated with homocysteine in healthy subjects.

Conclusions:

  • Diffusion Tensor Imaging (DTI) can detect microstructural white matter (WM) alterations related to homocysteine levels in healthy individuals.
  • This finding suggests that homocysteine may impact brain health at a microstructural level even before macroscopic changes are apparent.