Related Experiment Video
Updated: Apr 17, 2026

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
Published on: April 4, 2025
Looking for efficient G-quadruplex ligands: evidence for selective stabilizing properties and telomere damage by
Bruno Pagano1, Jussara Amato, Nunzia Iaccarino
1Department of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, 80131, Napoli (Italy).
Abstract:
There is currently significant interest in the development of G-quadruplex-interactive compounds, given the relationship between the ability to stabilize these non-canonical DNA structures and anticancer activity. In this study, a set of biophysical assays was applied to evaluate the binding of six drug-like ligands to DNA G-quadruplexes with different folding topologies. Interestingly, two of the investigated ligands showed selective G-quadruplex-stabilizing properties and biological activity. These compounds may represent useful leads for the development of more potent and selective ligands.
Related Concept Videos
Telomeres and Telomerase
Telomeres and Telomerase
Translesion DNA Polymerases
TLS polymerases are found in all three domains of life - archaea, bacteria, and eukaryotes. Of the different classes of TLS polymerases, members of the Y family are fitted with specialized structures that...
Inhibitors of Bacterial DNA Synthesis
Replication in Eukaryotes
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
Replication in Eukaryotes

