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Updated: Apr 17, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Evidence-based decision-making 7: Knowledge translation
1University of Calgary, 1403 - 29th Street NW, Calgary, AB, Canada, T2N 2T9, Braden.Manns@albertahealthservices.ca.
Knowledge translation bridges the evidence-to-practice gap in healthcare. The knowledge to action cycle guides implementing research findings into clinical practice with stakeholder involvement.
Area of Science:
- Health Services Research
- Implementation Science
Background:
- A significant gap exists between scientific knowledge and its application in clinical practice.
- Bridging this evidence-to-practice gap is crucial for improving healthcare outcomes.
Purpose of the Study:
- To describe the knowledge to action cycle as a framework for knowledge translation.
- To highlight the integration of policy-makers and stakeholders throughout the research and implementation process.
Main Methods:
- The knowledge to action cycle framework is presented.
- The cycle involves problem identification, knowledge creation, and knowledge application phases.
- Key components include adapting knowledge, assessing barriers, implementing interventions, and sustaining use.
Main Results:
- Knowledge creation synthesizes primary data into usable knowledge products like guidelines and decision aids.
- Knowledge application involves adapting, implementing, monitoring, evaluating, and sustaining interventions.
- The framework emphasizes bidirectional communication and stakeholder engagement.
Conclusions:
- The knowledge to action cycle provides a structured approach to knowledge translation.
- Effective knowledge translation requires active involvement of healthcare decision-makers and stakeholders.
- This framework facilitates the integration of research evidence into routine clinical practice.
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