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Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
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Aortic arch calcification predicts the renal function progression in patients with stage 3 to 5 chronic kidney

Lung-Chih Li1, Yueh-Ting Lee1, Yi-Wei Lee2

  • 1Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung District, Kaohsiung 833, Taiwan.

Biomed Research International
|February 20, 2015
PubMed

Insights

Aortic arch calcification (AoAC) and cardiomegaly together predict faster kidney function decline in chronic kidney disease (CKD) patients. AoAC independently impacts renal outcomes in advanced CKD.

Area of Science:

  • Nephrology
  • Cardiology
  • Radiology

Background:

  • Aortic arch calcification (AoAC) and cardiomegaly are known cardiovascular mortality risk factors in chronic kidney disease (CKD).
  • The relationship between AoAC, cardiomegaly, and kidney function decline in CKD patients is not fully understood.

Purpose of the Study:

  • To investigate if AoAC and cardiomegaly are independently associated with renal function progression in patients with stages 3-5 CKD.

Main Methods:

  • Retrospective analysis of 237 CKD patients (stages 3-5) followed for at least three years.
  • Chest X-rays were used to identify AoAC and cardiomegaly.
  • Renal function change was measured by the slope of estimated glomerular filtration rate (eGFR).

Main Results:

  • The group with both AoAC and cardiomegaly showed a significantly faster eGFR decline compared to other groups.
  • Baseline AoAC and proteinuria were independently linked to eGFR decline.
  • AoAC was independently determined by age, eGFR slope, and cardiomegaly.

Conclusions:

  • The combined presence of AoAC and cardiomegaly is associated with accelerated eGFR decline in CKD patients.
  • AoAC is an independent predictor of renal outcomes in patients with stages 3-5 CKD.
Abstract

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