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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
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Management of noninvasive bladder cancers
John B Eifler1, Kristen R Scarpato, Peter E Clark
1Department of Urological Surgery, Vanderbilt University Medical Center, South Nashville, Tennessee, USA.
Current Opinion in Oncology
|February 20, 2015
Summary
Clinical management of nonmuscle-invasive bladder cancer (NMIBC) benefits from advances in early detection and risk stratification. New therapies offer improved outcomes for NMIBC patients, potentially delaying radical treatments.
Area of Science:
- Urology
- Oncology
Background:
- Nonmuscle-invasive bladder cancer (NMIBC) is a prevalent and costly condition.
- Current management relies on prevention, early detection, and risk-adapted treatment strategies.
Purpose of the Study:
- To review the clinical management of NMIBC.
- To discuss recent advancements impacting NMIBC care.
Main Methods:
- Literature review of recent research in NMIBC.
- Analysis of new diagnostic and therapeutic modalities.
Main Results:
- Photodynamic diagnosis enhances early detection of NMIBC.
- Novel intravesical agents show promise for intermediate/high-risk NMIBC, potentially avoiding cystectomy after BCG failure.
- Improved risk stratification enables personalized NMIBC management.
Conclusions:
- NMIBC encompasses diverse disease states with evolving clinical behaviors.
- Enhanced detection and risk stratification are key to optimizing individual patient treatment for NMIBC.
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