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In-bore MRI interventions: current status and future applications.

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Multiparametric MRI enables precise, in-bore targeted focal treatment for prostate cancer (PCa), improving diagnosis and minimizing side effects compared to whole-gland therapies.

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Area of Science:

  • Oncology
  • Radiology
  • Medical Technology

Background:

  • Multiparametric MRI (mpMRI) enhances diagnosis and targeted therapy for prostate cancer (PCa).
  • Focal therapy aims to treat localized PCa, minimizing toxicity associated with whole-gland treatments.

Purpose of the Study:

  • To review the feasibility, recent advances, and current status of in-bore MRI-guided interventional techniques for focal PCa diagnosis and treatment.
  • To explore future applications and emerging strategies for PCa treatment.

Main Methods:

  • Review of current literature on in-bore MRI-guided interventions for PCa.
  • Analysis of preliminary results from ongoing clinical trials (Phase I and II) for in-bore focal PCa treatment.

Main Results:

  • MRI-guided targeted biopsy shows higher detection rates for significant PCa and lower rates for insignificant cancer.
  • In-bore MRI-guided focal therapy offers real-time thermal monitoring and immediate post-treatment assessment.
  • Preliminary trials using transperineal, transrectal, and transurethral routes with various ablation modalities show promising outcomes.

Conclusions:

  • Advances in mpMRI facilitate in-bore targeted focal treatment for appropriately selected PCa patients.
  • In-bore MRI guidance improves precision and monitoring in focal PCa therapy.