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Updated: Apr 17, 2026

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement
Published on: December 11, 2017
Prevalence of coronary atherosclerosis in patients with aortic valve replacement
Insights
Preoperative coronary angiography remains crucial for patients undergoing aortic valve replacement, as coronary artery disease prevalence is high and has not significantly changed over a decade. This ensures optimal patient care and surgical planning.
Area of Science:
- Cardiology
- Cardiac Surgery
- Diagnostic Imaging
Background:
- Coronary artery disease (CAD) is common in patients with aortic valve disease, necessitating preoperative coronary angiography before aortic valve replacement (AVR).
- Despite declining CAD mortality in the general population, the necessity of routine preoperative angiography for all AVR patients remains uncertain.
Purpose of the Study:
- To determine the prevalence of angiographically defined CAD in patients undergoing AVR.
- To analyze trends in CAD prevalence over a ten-year period (1988-1998) in this patient cohort.
Main Methods:
- Retrospective cross-sectional study of 1181 patients undergoing AVR between 1988 and 1998.
- Exclusion of patients with prior CAD history or younger than 25 years.
- Definition of coronary atherosclerosis as ≥50% stenosis in one or more coronary arteries via preoperative angiography.
Main Results:
- Coronary atherosclerosis was detected in 40% of patients (472/1181) on preoperative angiography.
- Prevalence of CAD varied annually between 30% and 50% but showed no significant trend over the study period.
- Known ischemic heart disease risk factors were associated with the presence of CAD.
Conclusions:
- The prevalence of angiographically confirmed CAD in patients awaiting AVR remains high.
- No significant temporal change in CAD prevalence was observed between 1988 and 1998.
- Preoperative coronary angiography is recommended for all patients prior to AVR due to the persistent high prevalence of CAD.
Background:
Because of a high prevalence of coronary artery disease in patients with aortic valve disease, coronary angiography is recommended before aortic valve replacement. However, during the last three decades, a decline in mortality due to coronary heart disease has been observed in the general population in both Western Europe and the United States. It is unknown whether preoperative angiography is still mandatory in all patients.
Aim:
To assess the prevalence of angiographically defined coronary artery disease in patients with aortic valve replacement and trends during a ten-year period.
Methods:
We performed a retrospective cross-sectional study of patients undergoing aortic valve replacement between 1988 and 1998 in our institution. Patients with a history of coronary artery disease and patients younger than 25 years were excluded. Coronary atherosclerosis was defined as one or more coronary artery luminal stenosis of 50% or more on preoperative coronary angiography.
Results:
During the study period 1339 patients had aortic valve replacement in our institution, data on 1322 (98%) were available for analysis. Previous coronary artery disease was documented in 124 patients (10%). After exclusion of 17 patients (no angiography), data on a total of 1181 patients were analysed. Coronary atherosclerosis was present in 472 patients (40%) on preoperative coronary angiography. Several well-known risk factors of ischaemic heart disease were associated with coronary atherosclerosis. The prevalence of angiographically defined coronary atherosclerosis varied between 30% and 50% per year. There was, however, no significant trend during the study period. Multivariate analyses, to adjust for potential differences in risk factors during the observation period, did not change this conclusion.
Conclusions:
The prevalence of angiographically defined coronary artery disease in patients scheduled for aortic valve replacement is still high. From 1988 to 1998, no significant change was observed in angiographic measures of coronary atherosclerosis in patients with aortic valve replacement. Therefore, it is advised to perform coronary angiography before aortic valve surgery.
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