Related Experiment Video

Updated: Jul 19, 2026

Myocardial Infarction and Functional Outcome Assessment in Pigs
12:03

Myocardial Infarction and Functional Outcome Assessment in Pigs

Published on: April 25, 2014

28.9K

DDDR pacing for symptomatic patients with hypertrophic obstructive cardiomyopathy: The first experience in the

H J Achterberg, M G Scheffer, R van Mechelen

    Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation
    |February 20, 2015
    PubMed

    Insights

    Dual-chamber pacing effectively reduces left ventricular outflow tract gradients and improves symptoms in patients with hypertrophic obstructive cardiomyopathy (HOCM). This safe treatment option offers sustained relief for drug-refractory cases.

    Area of Science:

    • Cardiology
    • Cardiac Electrophysiology

    Background:

    • Hypertrophic obstructive cardiomyopathy (HOCM) is a primary cardiac disorder with varied presentations.
    • Therapeutic options for symptomatic HOCM unresponsive to medical therapy include myectomy, septal ablation, and pacemaker implantation.

    Purpose of the Study:

    • To evaluate the efficacy and safety of dual-chamber pacemaker implantation for reducing left ventricular outflow tract (LVOT) gradients and alleviating symptoms in drug-refractory, symptomatic HOCM patients.

    Main Methods:

    • Dual-chamber pacemakers were implanted in seven patients with symptomatic HOCM (NYHA class 3-4, LVOT gradient >2.75 m/s) not eligible for surgery.
    • Pacemaker leads were positioned in the right ventricular apex and right atrial appendage, with AV settings optimized using Doppler echocardiography.

    Main Results:

    • A statistically significant reduction in LVOT gradient was observed in all patients (mean pre-implantation 4.7±1.1 m/s to 1.9±0.4 m/s post-implantation, p<0.001).
    • All patients experienced symptomatic improvement, with NYHA functional class improving from 3-4 to 1-2 (p<0.001).
    • Symptomatic improvement was maintained during a mean follow-up of 2.3 years.

    Conclusions:

    • Dual-chamber pacing is a safe and effective treatment for symptomatic HOCM.
    • Pacemaker therapy provides a viable alternative for patients with drug-refractory HOCM unsuitable for surgery.
    Abstract

    Keywords:
    DDDR pacinghypertrophic obstructive cardiomyopathy

    More Related Videos

    Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction14:19

    Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction

    Published on: October 14, 2016

    12.1K
    Robotic Pancreatoduodenectomy for Pancreatic Head Cancer: a Case Report of a Standardized Technique13:38

    Robotic Pancreatoduodenectomy for Pancreatic Head Cancer: a Case Report of a Standardized Technique

    Published on: June 24, 2022

    6.7K

    Related Concept Videos

    Pulse rhythm01:30

    Pulse rhythm

    Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
    Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac muscle...
    Cardiomyopathy II: Dilated Cardiomyopathy01:30

    Cardiomyopathy II: Dilated Cardiomyopathy

    Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
    Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

    Cardiomyopathy III: Hypertrophic Cardiomyopathy

    Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
    Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

    Cardiomyopathy IV: Restrictive Cardiomyopathy

    Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
    Cardiomyopathy V: Interprofessional Care01:29

    Cardiomyopathy V: Interprofessional Care

    Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
    Cardiomyopathy VII: Pre and Post Operative Nursing Management01:28

    Cardiomyopathy VII: Pre and Post Operative Nursing Management

    Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...