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Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
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Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

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Hypertrophic cardiomyopathy in daily practice: an introduction on diagnosis, prognosis and treatment

C van der Lee, M J Kofflard, M L Geleijnse

    Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation
    |February 20, 2015
    PubMed

    Insights

    Hypertrophic cardiomyopathy (HCM) is an inherited heart condition. This review details its diagnosis, prognosis, and diverse treatment strategies, including invasive options for severe cases.

    Area of Science:

    • Cardiology
    • Genetics
    • Internal Medicine

    Background:

    • Hypertrophic cardiomyopathy (HCM) is a complex inherited cardiac disease.
    • Understanding of HCM diagnosis, prognosis, and treatment has evolved significantly since its initial description in 1957.
    • Recent analyses have refined insights into HCM's natural history and sudden cardiac death risk.

    Approach:

    • This report summarizes current diagnostic criteria for HCM.
    • It reviews the clinical course and therapeutic management of HCM.
    • Special attention is given to specific issues relevant to HCM.

    Key Points:

    • Optimal HCM therapy is individualized based on symptoms, hemodynamics, and sudden cardiac death risk factors.
    • Sudden cardiac death is the most devastating aspect of HCM's natural history.
    • Invasive therapies like surgery or septal ablation are options for obstructive, drug-refractory HCM.

    Conclusions:

    • HCM management requires a comprehensive approach considering disease progression and patient-specific factors.
    • Continued research is crucial for improving outcomes in patients with hypertrophic cardiomyopathy.
    • This review provides a consolidated overview for clinicians managing HCM.

    Keywords:
    cardiiomyopathymyectomyseptal ablation

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