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Anaemia predicts cardiovascular events in patients with stable coronary artery disease
Insights
Anaemia is a significant risk factor for cardiovascular events in patients with coronary artery disease (CAD). This study found that anaemia independently predicts adverse outcomes in these patients, highlighting its prognostic value.
Area of Science:
- Cardiology
- Hematology
Background:
- Anaemia is a known risk factor for cardiovascular events in heart failure and chronic kidney disease patients.
- The prognostic impact of anaemia in coronary artery disease (CAD) patients is not well-established.
Purpose of the Study:
- To investigate the prognostic value of anaemia in patients with established coronary artery disease (CAD).
Main Methods:
- 143 patients with stable angina and significant CAD (>50% stenosis) undergoing coronary angiography were analyzed.
- Cardiovascular events included death, myocardial infarction, and unstable angina hospitalization.
- Anaemia was defined by WHO criteria (Hb ≤8 mmol/l men, ≤7.5 mmol/l women).
Main Results:
- The study population mean age was 61.5±9.4 years.
- During 44±19 months follow-up, 19 cardiovascular events occurred.
- Anaemia independently predicted cardiovascular events (HR 5.73, P=0.01) after adjusting for risk factors.
Conclusions:
- Anaemia is associated with poorer outcomes in patients with established CAD.
- Anaemia can serve as a valuable prognostic indicator in this patient group.
Background:
Anaemia is an independent risk factor for cardiovascular (CV) events in patients with heart failure and patients with chronic kidney disease. The effect of anaemia on CV outcomes in patients with coronary artery disease (CAD) remains unclear. Therefore, we investigated the prognostic value of anaemia in this group of patients.
Methods:
Patients with stable angina pectoris, referred for a first diagnostic coronary angiography, were eligible for this study. Only subjects with significant coronary artery disease (>50% luminal narrowing) were used for analysis (n=143). Cardiovascular events were defined as cardiovascular death, acute myocardial infarction and hospitalisation for unstable angina pectoris. Anaemia was defined according to WHO criteria as haemoglobin level ≤8 mmol/l in men and ≤7.5 mmol/l in women.
Results:
The mean age of the population was 61.5±9.4 years. During follow-up (44±19 months), 19 CV events occurred. The diagnosis of anaemia predicted CV events, even when adjusted for other risk factors (hazard ratio 5.73, 95% confidence interval 1.49-22.13, p=0.01). In univariate analysis, serum erythropoietin levels predicted CV outcomes (p<0.05); however, this association was lost when adjusted for haemoglobin concentration.
Conclusion:
Anaemia is associated with worse outcome in patients with established CAD and could be used as a prognostic indicator in this group of patients.
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