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Updated: Jan 25, 2026
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Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro
Published on: May 10, 2021
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A nineteen-millimetre aortic valve prosthesis: is this really a risk?
Summary
Aortic valve replacement using 19 mm prostheses in patients with small aortic roots is feasible. This procedure offers excellent symptomatic improvement and enhanced quality of life, with acceptable hospital mortality.
Area of Science:
- Cardiovascular Surgery
- Thoracic Surgery
- Cardiac Valve Surgery
Background:
- Aortic valve replacement (AVR) in patients with small aortic roots remains controversial.
- This study reviews clinical experience with 19 mm AVR prostheses and relevant literature.
Purpose of the Study:
- To evaluate the safety and efficacy of AVR using 19 mm prostheses in patients with small aortic roots.
- To assess clinical outcomes, including mortality, survival, and functional improvement.
Main Methods:
- Retrospective analysis of 51 patients who received 19 mm AVR prostheses between 1994 and 1999.
- Data collection included patient demographics, comorbidities, operative risk (EuroSCORE), and follow-up outcomes.
- Literature review combined with clinical experience.
Main Results:
- Hospital mortality was 7.8% (4/51 patients).
- Survival rates at 12, 24, and 48 months were 90%, 85%, and 60%, respectively.
- 85% of patients experienced at least a one-class improvement in NYHA class, with 34 reporting improved quality of life.
Conclusions:
- AVR with small (19 mm) prostheses is a viable option for patients with small aortic roots.
- The procedure demonstrates acceptable operative mortality.
- Excellent symptomatic improvement and enhanced quality of life were observed post-operatively.
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