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Related Experiment Video

Updated: Apr 17, 2026

Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System
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[Metabolic syndrome and melatonin].

S I Rapoport, A Iu Molchanov, V A Golichenkov

    Klinicheskaia Meditsina
    |February 21, 2015
    PubMed
    Summary

    Melatonin may help treat metabolic syndrome (MS) by inhibiting key pathophysiological processes like insulin resistance and dyslipidemia. This hormone

    Area of Science:

    • Biochemistry
    • Endocrinology
    • Metabolic Research

    Background:

    • Metabolic syndrome (MS) involves obesity, hypertension (AH), dyslipidemia, and insulin resistance.
    • Pathophysiology includes elevated LDL, pancreatic beta-cell hyperstimulation, and altered lipid metabolism.
    • Obesity leads to excess adiponectin and leptin, increasing their concentration.

    Purpose of the Study:

    • To investigate the role of melatonin in metabolic syndrome.
    • To explore melatonin's potential therapeutic effects on MS pathophysiology.

    Main Methods:

    • Review of endogenous and exogenous melatonin's inhibitory mechanisms on MS pathways.
    • Examination of melatonin's interaction with MT1 and MT2 receptors.
    • Analysis of existing research on melatonin's therapeutic effects in MS.

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    Main Results:

    • Melatonin inhibits MS pathophysiological mechanisms, including insulin resistance and dyslipidemia.
    • It normalizes metabolism, equilibrates insulin secretion, and prevents pancreatic hyperfunction.
    • Melatonin inactivates reactive oxygen and nitrogen species and phosphorylates insulin receptors.

    Conclusions:

    • Melatonin demonstrates a combined preventive action in MS patients due to its widespread cellular receptors.
    • Emerging evidence suggests melatonin has a therapeutic effect and may be recommended for treating MS.