[The influence of testosterone and β-estradiol on T-lymphocytes activation associated with IL-2 production and

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A A Gutsol, N A Sokhonevich, K A Kofanova

    Tsitologiia
    |February 21, 2015
    PubMed

    We have shown that testosterone and β-estradiol in vitro have effects on naïve (CD45RA+) and priming (CD45RO+) T-lymphocytes, which associated with the production of IL-2 and CD25/IL-2Rα expression. Testosterone can inhibit naïve and priming T-cell function activity in our study. Moreover it was shown that naïve lymphocytes are more sensitive to testosterone than primed. We have found dose dependent suppressive β-estradiol effect on IL-2 production by activated CD45RA+ and CD45RO+ lymphocytes which leads to uniform decreasing CD25-positive T-cells number.

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