Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Morphologic differences between polyarteritis and Wegener's granulomatosis using light, electron and

T T Antonovych1, S G Sabnis, S M Tuur

  • 1Department of Genitourinary Pathology, Armed Forces Institute of 4athology, Washington, D.C.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
|July 1, 1989
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ERG rearrangement and protein expression in the progression to castration-resistant prostate cancer.

Prostate cancer and prostatic diseases·2014
Same author

Elevated osteonectin/SPARC expression in primary prostate cancer predicts metastatic progression.

Prostate cancer and prostatic diseases·2012
Same author

Laser-capture microdissection.

Methods in molecular medicine·2011
Same author

Overexpression of C-MYC oncogene in prostate cancer predicts biochemical recurrence.

Prostate cancer and prostatic diseases·2010
Same author

ERG oncoprotein expression in prostate cancer: clonal progression of ERG-positive tumor cells and potential for ERG-based stratification.

Prostate cancer and prostatic diseases·2010
Same author

Treatment of type B insulin resistance: a novel approach to reduce insulin receptor autoantibodies.

The Journal of clinical endocrinology and metabolism·2010

Differentiating polyarteritis nodosa (PAN) from Wegener's granulomatosis (WG) in kidney biopsies is challenging. This study highlights key morphologic, cellular, and vascular differences in glomerulonephritis to aid diagnosis.

Area of Science:

  • Nephrology
  • Pathology
  • Immunology

Background:

  • Distinguishing polyarteritis nodosa (PAN) from Wegener's granulomatosis (WG) in renal biopsies is diagnostically challenging.
  • Both conditions can present as focal proliferating and necrotizing glomerulonephritis (GN) with crescents.

Purpose of the Study:

  • To identify distinct histological, ultrastructural, and immunohistochemical features differentiating PAN from WG in renal biopsies.
  • To improve the accuracy of differential diagnosis between these two vasculitic diseases affecting the kidneys.

Main Methods:

  • Comparative analysis of 29 PAN and 29 WG renal biopsies.
  • Utilized light microscopy, electron microscopy, and immunohistochemistry.
  • Examined glomerular morphology, crescent formation, necrotizing arteritis, and cellular infiltrates.

Related Experiment Videos

Main Results:

  • PAN shows severe focal fibrinoid necrosis of glomerular tufts and common necrotizing arteritis.
  • WG is characterized by destructive extracapillary GN with capsular breaks, periglomerulitis, and granuloma formation.
  • PAN biopsies predominantly feature polymorphonuclear cells (PMNs), while WG shows a predominance of mononuclear cells.

Conclusions:

  • Distinct morphologic and cellular differences exist between PAN and WG renal biopsies.
  • Histologic evaluation, including assessment of arteritis and cellular composition, is crucial for differential diagnosis.
  • These findings aid in distinguishing PAN from WG, improving patient management.