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Related Experiment Video

Updated: Apr 17, 2026

A Contemporary Warming/Restraining Device for Efficient Tail Vein Injections in a Murine Fungal Sepsis Model
06:02

A Contemporary Warming/Restraining Device for Efficient Tail Vein Injections in a Murine Fungal Sepsis Model

Published on: November 6, 2020

18.8K

Terminal-stage prognostic analysis in candidemia.

Takahiro Takuma1, Hisashi Shoji1, Yoshihito Niki1

  • 1Department of Medicine, Division of Clinical Infectious Diseases, School of Medicine, Showa University, Tokyo, Japan.

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
|February 21, 2015
PubMed
Summary

Determining the cause of death in candidemia patients is complex. This study found that patient background and comorbidities, not just candidemia, significantly impact mortality, with delayed antifungal therapy linked to better survival outcomes.

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Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Epidemiology

Background:

  • Candidemia presents a high mortality rate, yet its direct contribution to death is challenging to ascertain.
  • Understanding factors influencing mortality in candidemia is crucial for effective patient management.

Purpose of the Study:

  • To identify prognostic factors associated with mortality in patients diagnosed with culture-proven candidemia.
  • To evaluate the impact of comorbid conditions and clinical prognostic stages on survival rates.

Main Methods:

  • A cohort study was conducted at two Japanese university hospitals from April 2009 to May 2013.
  • The Charlson comorbidity index and subjective clinical prognostic stages were assessed.
  • Cox proportional hazard models were employed for univariate and multivariate survival analyses.
Keywords:
BiasCandidemiaCox proportional hazard modelMortalityPrognosis

Related Experiment Videos

Last Updated: Apr 17, 2026

A Contemporary Warming/Restraining Device for Efficient Tail Vein Injections in a Murine Fungal Sepsis Model
06:02

A Contemporary Warming/Restraining Device for Efficient Tail Vein Injections in a Murine Fungal Sepsis Model

Published on: November 6, 2020

18.8K

Main Results:

  • Univariate analysis revealed increased mortality linked to internal medicine admission, Candida glabrata, immunosuppression, hypotension, hypoxemia, and terminal prognostic stage.
  • Decreased mortality was associated with serum albumin, endophthalmitis investigation, and nonterminal prognostic stage.
  • Multivariate analysis confirmed prognostic stage (P < 0.0001), age (P = 0.0014), and delayed antifungal therapy (P = 0.0374) as significant factors affecting survival.

Conclusions:

  • Contrary to previous findings, delayed antifungal therapy was associated with decreased mortality in candidemia.
  • Patient background and comorbidity status were more critical determinants of death than candidemia itself.
  • Rigorous methodologies are essential for accurately determining causes of death in critically ill candidemia patients.