Interest of antioxidant agents in parasitic diseases. The case study of coumarins

Roberto Figueroa-Guiñez, Maria João Matos, Saleta Vazquez-Rodriguez

  • 1Departamento de Quimica Inorganica y Analitica, Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile, Santiago. colea@uchile.cl.

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Oxidation of Phenols to Quinones

In the presence of oxidizing agents, phenols are oxidized to quinones. Quinones can be easily reduced back to phenols using mild reducing agents. The electron-donating hydroxyl group enhances the reactivity of the aromatic ring, enabling oxidation of the ring even in the absence of an α hydrogen.
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox...
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Anticholinesterase Agents: Poisoning and Treatment01:26

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Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.     
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