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Human gene for proliferating cell nuclear antigen has pseudogenes and localizes to chromosome 20
D H Ku1, S Travali, B Calabretta
1Department of Pathology, Temple University School of Medicine, Philadelphia, Pennsylvania.
Somatic Cell and Molecular Genetics
|July 1, 1989
Abstract:
We have isolated from a human genomic library a pseudogene of the proliferating cell nuclear antigen (PCNA) gene. Its sequence shows a 78% similarity with the human PCNA/cDNA. The PCNA gene is located on human chromosome 20, while the pseudogene maps to chromosome region Xpter in equilibrium Xq13. An additional locus detected by the full-length PCNA cDNA, but not by intron probes, segregates concordantly with chromosome region 6p12 in equilibrium 6pter and probably represents a second pseudogene.