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DNA-functionalized Pt nanoparticles as catalysts for chemically powered micromotors: toward signal-on motion-based
Khiem Van Nguyen1, Shelley D Minteer
1Departments of Chemistry and Materials Science and Engineering, 315 S 1400 E Room 2020, Salt Lake City, UT 84112, USA. minteer@chem.utah.edu.
Chemical Communications (Cambridge, England)
|February 21, 2015
Abstract:
We present here the construction of a DNA biosensor based on a tubular micromotor that only produces motion-based signal in the presence of DNA target. This "turn on" characteristic of the sensor is achieved by the addition of Pt nanoparticle-DNA conjugate as the motion-inducing catalyst for the micromotors through DNA hybridization. Our work potentially offers new design strategies for motion-based biosensors with higher specificity.
