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Related Concept Videos

Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
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A Culture Method to Maintain Quiescent Human Hematopoietic Stem Cells
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A Culture Method to Maintain Quiescent Human Hematopoietic Stem Cells

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Stem cell quest.

Alexandra Irvine1

  • 1Department of Haematology, Centre for Cancer Research and Cell Biology, Queen's University of Belfast, Belfast, UK, s.irvine@qub.ac.uk.

Journal of Cell Communication and Signaling
|February 21, 2015
PubMed
Summary
This summary is machine-generated.

Chronic Myeloid Leukaemia (CML) research identified a specific sub-population of leukaemic stem cells. Targeting CD26 on these cells offers a potential new curative therapy for CML patients.

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Area of Science:

  • Hematology
  • Cancer Biology
  • Molecular Medicine

Background:

  • Chronic Myeloid Leukaemia (CML) is a hematologic malignancy characterized by a specific genetic alteration in over 95% of patients.
  • Tyrosine kinase inhibitors (TKIs) have significantly improved patient outcomes since their introduction in 2000.
  • Despite TKI efficacy, drug resistance remains a challenge, and CML is typically controlled rather than eradicated.

Purpose of the Study:

  • To identify the specific leukaemic stem cell sub-population responsible for CML propagation.
  • To explore novel therapeutic targets beyond current TKI treatments.

Main Methods:

  • Analysis of leukaemic stem cell populations in CML patients.
  • Identification of specific cell surface markers associated with disease propagation.

Main Results:

  • A distinct sub-population of leukaemic stem cells driving CML has been defined.
  • CD26 has been identified as a specific target on these malignant stem cells.

Conclusions:

  • Targeting CD26 presents a promising new strategy for achieving a true curative therapy for CML.
  • This discovery could lead to more effective and potentially curative treatments for CML, overcoming current therapeutic limitations.