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Related Experiment Video

Updated: Apr 17, 2026

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis
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Properdin levels in human sepsis.

Cordula M Stover1, John McDonald2, Simon Byrne1

  • 1Department of Infection, Immunity and Inflammation, College of Medicine, Biological Sciences and Psychology, University of Leicester , Leicester , UK.

Frontiers in Immunology
|February 21, 2015
PubMed
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Properdin levels are decreased in sepsis patients upon ICU admission but rise after recovery. Low properdin concentrations in sepsis indicate a poorer prognosis and longer treatment duration.

Area of Science:

  • Immunology
  • Complement System Biology

Background:

  • Properdin amplifies complement activation, aiding infection resolution but potentially causing tissue damage.
  • Complement C3 levels decrease in human sepsis, despite C3 being an acute phase reactant.
  • Properdin's role in human sepsis remains uncharacterized.

Purpose of the Study:

  • To investigate properdin serum concentrations in critically ill sepsis patients.
  • To compare properdin levels between sepsis patients and healthy volunteers.
  • To correlate properdin levels with clinical outcomes and disease severity.

Main Methods:

  • Serum properdin levels were measured in 81 sepsis patients and 61 healthy controls.
  • Measurements were taken at defined intervals during intensive care unit (ICU) stays.
Keywords:
complementintensive careproperdinrecoverysepsis

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  • Properdin concentrations were compared between survivors and non-survivors and correlated with APACHE II scores.

    • Main Results:

    • Properdin levels were significantly lower in sepsis patients upon ICU admission compared to healthy volunteers.
    • Properdin concentrations increased after clinical recovery, surpassing levels in healthy individuals.
    • Lower initial properdin levels were associated with decreased survival rates and longer treatment durations, but not APACHE II scores.

    Conclusions:

    • Properdin levels dynamically change during sepsis, decreasing upon admission and increasing with recovery.
    • Low properdin concentrations at ICU admission are a potential indicator of poor prognosis in sepsis.
    • Properdin may serve as a biomarker for sepsis severity and treatment duration.