Related Experiment Video
Updated: Apr 17, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
A case of typhoid Fever with hepatic granulomas and enteritis
Shraddha Narechania1, Marc Duran2, Vidhya Karivedu1
1Fairview Hospital, Cleveland, OH 44111, USA.
Abstract:
The common histopathologic hepatic manifestations in patients infected with Salmonella include cloudy swelling and balloon degeneration with vacuolation of the hepatocytes and steatosis. Hepatic granulomas are a very rare finding, so far reported in very few cases. We report a 64-year-old patient with Salmonella enteritis who was found to have multiple 1.4 to 1.6 cm hypoechoic liver masses on ultrasound of the abdomen which on biopsy revealed hepatic granulomas. This case highlights the importance of keeping the differential diagnosis of Salmonella typhi (S. typhi) in mind in a patient with hepatic granulomas.
Insights
Hepatic granulomas are rare in Salmonella infections. This case report details a Salmonella enteritis patient whose liver masses were diagnosed as hepatic granulomas, emphasizing Salmonella typhi as a differential diagnosis.
Area of Science:
- Hepatology
- Infectious Diseases
- Pathology
Background:
- Common Salmonella infections cause liver issues like steatosis and cloudy swelling.
- Hepatic granulomas are exceptionally rare findings in Salmonella infections, with few documented cases.
Purpose of the Study:
- To report a rare case of hepatic granulomas in a patient with Salmonella enteritis.
- To underscore the importance of considering Salmonella typhi in the differential diagnosis of hepatic granulomas.
Main Methods:
- A case study of a 64-year-old patient with Salmonella enteritis.
- Abdominal ultrasound revealed multiple hypoechoic liver masses.
- Liver biopsy confirmed the presence of hepatic granulomas.
Main Results:
- The patient presented with Salmonella enteritis.
- Ultrasound identified multiple liver masses (1.4-1.6 cm).
- Biopsy confirmed these masses were hepatic granulomas.
Conclusions:
- This case highlights a rare manifestation of Salmonella infection.
- Salmonella typhi should be considered in the differential diagnosis for patients presenting with hepatic granulomas.
Related Concept Videos
Hepatitis
Bacterial Gastroenteritis
Pulmonary Tuberculosis III
The first classification is based on the development of the disease, and it includes the following categories:
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Diseases of the Liver and Gallbladder
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...

