Related Experiment Video

Updated: Apr 17, 2026

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
05:53

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates

Published on: July 6, 2013

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Cytomegalovirus in human brain tumors: Role in pathogenesis and potential treatment options

Cecilia Söderberg-Nauclér1, John Inge Johnsen1

  • 1Cecilia Söderberg-Nauclér, Experimental Cardiovascular Research Unit, Department of Medicine, Solna, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm, Sweden.

World Journal of Experimental Medicine
|February 21, 2015
PubMed

Insights

Human cytomegalovirus (CMV) may drive brain tumor development and progression. Revisiting antiviral therapies against CMV shows promise for halting cancer growth and reducing mortality.

Area of Science:

  • Oncology
  • Virology
  • Neuro-oncology

Background:

  • Increasing evidence links human cytomegalovirus (CMV) to various human malignancies.
  • CMV infection is implicated in the initiation, progression, and metastasis of brain tumors.

Purpose of the Study:

  • To review and discuss the mechanisms by which CMV contributes to brain tumor development.
  • To explore the potential of anti-CMV therapies in managing brain cancers.

Main Methods:

  • Literature review and discussion of existing evidence on CMV and brain tumors.
  • Analysis of preclinical data from CMV-positive xenografts.
  • Review of clinical observations in CMV-positive glioblastoma patients.

Main Results:

  • CMV infection may influence brain tumor initiation, progression, and metastasis.
  • Anti-CMV treatment demonstrated impaired tumor growth in animal models.
  • Potential for increased survival in CMV-positive glioblastoma patients receiving anti-CMV treatment.

Conclusions:

  • CMV possesses significant tumor-promoting capabilities, particularly in brain tumors.
  • Antiviral therapies targeting CMV warrant further investigation as a potential cancer treatment strategy.
  • Revisiting CMV antiviral therapies could offer a promising approach to reduce cancer progression and mortality.
Keywords:
Brain tumorCytomegalovirusGlioblastomaMedulloblastomaOncovirus

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