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A new path to leukemia with WIT
Jose Luis Sardina1, Thomas Graf1
1Center for Genomic Regulation, C/Dr. Aiguader, 88, PRBB Building, 08003 Barcelona, Spain; Pompeu Fabra University, Plaça de la Mercè, 10, 08002 Barcelona, Spain.
Molecular Cell
|February 21, 2015
Abstract:
In this issue, Wang et al., 2015 describes that WT1 recruits TET2 to the DNA, an important feature of a new regulatory pathway linked to the development of acute myeloid leukemia (AML). This pathway consists of WT1, IDH1/2, and TET2 (WIT) genes, with exclusive mutations of the three genes inducing myeloid cell proliferation.