Functional connectivity during rested wakefulness predicts vulnerability to sleep deprivation
B T Thomas Yeo1, Jesisca Tandi2, Michael W L Chee2
1Center for Cognitive Neuroscience, Neuroscience & Behavioral Disorders Program, Duke-NUS Graduate Medical School, Singapore; Department of Electrical & Computer Engineering, Clinical Imaging Research Center & Singapore Institute for Neurotechnology, National University of Singapore, Singapore.
Neuroimage
|February 22, 2015
Summary
Sleep deprivation reduces brain network integration and segregation. Resilient individuals maintain clearer network separation, highlighting the importance of whole brain signal regression in sleep deprivation studies.
Area of Science:
- Neuroscience
- Cognitive Science
Background:
- Vigilance declines significantly after sleep deprivation, with notable individual differences.
- Understanding the neural basis of resilience to sleep deprivation is crucial.
Purpose of the Study:
- To characterize functional brain connectivity changes following total sleep deprivation.
- To identify neural correlates of resilience to vigilance decline.
Main Methods:
- Functional connectivity analysis in 68 healthy adults during rested wakefulness and after sleep deprivation.
- Whole brain signal regression was employed to analyze cortical and subcortical-cortical networks.
Main Results:
- Sleep deprivation reduced correlations in integrated cortical networks and decreased anti-correlations in segregated networks.
- Resilient individuals exhibited stronger anti-correlations, indicating clearer network segregation.
- Subcortical-cortical connectivity was similar between resilient and vulnerable groups.
Conclusions:
- Sleep deprivation disrupts the balance between integration and segregation in cortical networks.
- Enhanced segregation in well-rested states may confer resilience to vigilance decline.
- Regressing the whole brain signal is recommended for accurate analysis of sleep deprivation effects.
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