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Five days versus one day of penicillin as prophylaxis in elective neurosurgical operations
T D Cartmill1, M F al Zahawi, P R Sisson
1Department of Microbiology, Regional Public Health Laboratory, Newcastle-upon-Tyne, UK.
Abstract:
Of 423 patients undergoing elective cranial and spinal operations, infections due to Staphylococcus aureus occurred in 3 of 217 (1.4%) receiving penicillin for 1 day, in none of 206 receiving penicillin for 5 days. There was no significant difference in rates of infection between the two groups receiving penicillin. It is concluded that penicillin for 1 day is as effective as penicillin for 5 days, in the prevention of wound infections due to S. aureus.
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