Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Isolation of Lipid Rafts (Detergent-Resistant Microdomains) and Comparison to Extracellular Vesicles (Exosomes).

Methods in molecular biology (Clifton, N.J.)·2020

Same author

Global Brain Transcriptome Analysis of a Tpp1 Neuronal Ceroid Lipofuscinoses Mouse Model.

ASN neuro·2019

Same author

Connecting Exosomes and Connexins.

Cancers·2019

Same author

The cross roles of sphingosine kinase 1/2 and ceramide glucosyltransferase in cell growth and death.

Biochemical and biophysical research communications·2018

Same author

Quantum dots and potential therapy for Krabbe's disease.

Journal of neuroscience research·2016

Same author

Quantum dot-mediated delivery of siRNA to inhibit sphingomyelinase activities in brain-derived cells.

Journal of neurochemistry·2016

Same journal

Cumulative Contents.

Biochimica et biophysica acta·2020

Same journal

Molecular Basis of Disease Cumulative Contents.

Biochimica et biophysica acta·2020

Same journal

General Subjects Cumulative Contents.

Biochimica et biophysica acta·2020

Same journal

Erratum to 'on the role of exchangeable hydrogen bonds for the kinetics of P680<sup>+·</sup> Q<sub>A</sub> <sup>-·</sup> formation and P680<sup>+·</sup> Pheo<sup>-·</sup> recombination in photosystem II' [Biochim. Biophys. Acta 1276 (1996) 35-44].

Biochimica et biophysica acta·2019

Same journal

Oligomeric state of the light-harvesting complexes B800-850 and B875 from purple bacterium Rubrivivax gelatinosus in detergent solution.

Biochimica et biophysica acta·2019

Same journal

Regulation of pigment content and enzyme activity in the cyanobacterium Nostoc sp. Mac grown in continuous light, a light-dark photoperiod, or darkness.

Biochimica et biophysica acta·2019

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 17, 2026

Lipidomics and Transcriptomics in Neurological Diseases

Lipidomics and Transcriptomics in Neurological Diseases

Published on: March 18, 2022

Measuring brain lipids.

¹Dept. Pediatrics, University of Chicago, Chicago, IL 60637, USA.

Biochimica Et Biophysica Acta

|February 22, 2015

Summary

This summary is machine-generated.

This review highlights modern lipidomics techniques for analyzing brain lipids, addressing challenges from brain heterogeneity and developmental changes. It serves as a reference for brain lipid analysis, covering extraction, mass spectrometry, and future directions.

Keywords:

Brain lipids Mass-spectrometry Phospholipids Sphingolipids

More Related Videos

Sample Preparation for Rapid Lipid Analysis in Drosophila Brain Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging

Sample Preparation for Rapid Lipid Analysis in Drosophila Brain Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging

Published on: July 14, 2022

Measuring Post-Stroke Cerebral Edema, Infarct Zone and Blood-Brain Barrier Breakdown in a Single Set of Rodent Brain Samples

Measuring Post-Stroke Cerebral Edema, Infarct Zone and Blood-Brain Barrier Breakdown in a Single Set of Rodent Brain Samples

Published on: October 23, 2020

Related Experiment Videos

Last Updated: Apr 17, 2026

Lipidomics and Transcriptomics in Neurological Diseases

Lipidomics and Transcriptomics in Neurological Diseases

Published on: March 18, 2022

Sample Preparation for Rapid Lipid Analysis in Drosophila Brain Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging

Sample Preparation for Rapid Lipid Analysis in Drosophila Brain Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging

Published on: July 14, 2022

Measuring Post-Stroke Cerebral Edema, Infarct Zone and Blood-Brain Barrier Breakdown in a Single Set of Rodent Brain Samples

Measuring Post-Stroke Cerebral Edema, Infarct Zone and Blood-Brain Barrier Breakdown in a Single Set of Rodent Brain Samples

Published on: October 23, 2020

Area of Science:

Lipidomics
Neuroscience
Analytical Chemistry

Background:

Lipidomics is a rapidly advancing field driven by analytical technology.
The brain's structural, functional, and cellular heterogeneity presents unique challenges for lipid analysis.
Developmental changes (myelination, aging, pathology) and cellular diversity (neurons, glia) further complicate brain lipid studies.

Purpose of the Study:

To review modern analytical approaches in lipidomics, focusing on brain and nervous tissue.
To provide a reference for the analysis of various lipid classes in the brain.
To discuss challenges and future directions in brain lipidomics.

Main Methods:

Extraction techniques for yielding lipids from brain tissue.
Chromatography and mass spectrometry for comprehensive brain lipid analysis.
Methods for analyzing specific, low-abundance biologically active brain lipids.

Main Results:

Discussion of modern analytical technologies over earlier methods.
Identification of key challenges in brain lipid analysis due to heterogeneity and development.
Overview of techniques applicable to diverse brain lipid classes.

Conclusions:

Modern analytical techniques are crucial for advancing brain lipidomics.
Understanding brain lipid profiles requires addressing its complex heterogeneity.
Future research directions include experimental lipidomic modification in the brain.