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Candidial Endocarditis: A Single-Institute Pathological Analysis

Pradeep Vaideeswar1

  • 1Department of Pathology (Cardiovascular and Thoracic Division), Seth GS Medical College, Parel, Mumbai, 400012, India, shreeprajai@yahoo.co.in.

Mycopathologia
|February 23, 2015
PubMed

Insights

Candidial endocarditis, a fungal infection of the heart lining, is often linked to healthcare. This study highlights its right-sided, valvular nature and associated risk factors like central venous catheters.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Pathology

Background:

  • Infective endocarditis (IE) is increasingly associated with medical interventions.
  • Fungal IE accounts for a significant portion of IE cases, with Candida species being predominant.
  • Candidial endocarditis presents unique challenges in diagnosis and management.

Purpose of the Study:

  • To describe the pathological experience of candidial endocarditis.
  • To identify risk factors and clinical characteristics of candidial endocarditis.
  • To analyze outcomes and complications of candidial endocarditis.

Main Methods:

  • A retrospective analysis of 14 cases of candidial endocarditis.
  • Inclusion of surgically excised cardiac tissues and autopsied cases over a 14-year period.
  • Review of clinical data, risk factors, and autopsy findings.

Main Results:

  • Candidial endocarditis was predominantly right-sided and valvular.
  • Healthcare-associated invasive infections were observed in 12 of 14 cases.
  • Key risk factors included underlying heart disease, central venous catheterization, and prolonged antibiotic therapy.
  • Only five cases were diagnosed antemortem.
  • Mortality in autopsied patients was linked to septicemia and embolic complications.

Conclusions:

  • Candidial endocarditis is a significant complication of healthcare-associated infections.
  • Early diagnosis and prompt management are crucial for improving outcomes.
  • Understanding risk factors is essential for prevention and early detection.

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