[Effects of myelopeptide-1 on functional activity of murine phagocytes treated with cyclophosphan]

The effects of bone marrow derived myelopeptide-1 (MP-1) on functional activities of normal murine phagocytes and phagocytes obtained from mice treated with cytostatic agent cyclophosphan (CY) were studied in vivo and in vitro. We demonstrated immunocorrecting effect of MP-1 on functional activity of bone marrow and peripheral blood phagocytes. An optimal protocol of MP-1 injections during cytostatic therapy was developed to obtain maximal efficacy in immunocorrection. The best effect on functional activity of phagocytes of different localization (the highest effect on peripheral blood neutrophils) was found when MP-1 was injected before CY. The results demonstrated that MP-1 can be considered as a substance able to protect peripheral blood phagocytes from CY damage during cytostatic treatment.