Related Experiment Video
Updated: Apr 17, 2026
04:38
A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
Published on: May 22, 2019
11.0K
The relationship between post-stroke depression and physical recovery.
Shiho Matsuzaki1, Mamoru Hashimoto2, Seiji Yuki2
1Department of Neuropsychiatry, Graduate School of Medical Science, Kumamoto University, Kumamoto, Japan.
Journal of Affective Disorders
|February 24, 2015
Summary
Post-stroke depression and apathy can independently affect physical recovery. Objective assessments during hospitalization are crucial for accurately estimating and enhancing functional outcomes in stroke survivors.
Area of Science:
- Neuroscience
- Psychiatry
- Rehabilitation Medicine
Background:
- Post-stroke depression (PSD) is a frequent complication impacting stroke recovery.
- Distinguishing depression from apathy and understanding assessment timing are critical.
- This study investigates the interplay between PSD, apathy, and physical function.
Purpose of the Study:
- To differentiate the effects of depression and apathy on physical recovery post-stroke.
- To evaluate the impact of assessment methods (subjective vs. objective) on PSD prevalence.
- To determine optimal timing for assessing depression and apathy for functional recovery.
Main Methods:
- 117 Japanese stroke patients were assessed using self-rating (SDS, AS) and observer-rating scales (MADRS, NPI-NH).
- Physical disability was measured using the Functional Independence Measurement (FIM).
- Two-way ANCOVA analyzed the effects of depression and apathy on FIM scores at two time points.
Main Results:
- Objective scales indicated higher prevalence for both depression and apathy compared to subjective scales.
- Apathy significantly impacted FIM recovery when assessed objectively during hospitalization.
- Depression showed a marginal effect on FIM recovery during the same period.
Conclusions:
- Depression and apathy can occur independently and influence functional recovery differently.
- Objective measures provide more accurate estimates of functional recovery post-stroke.
- Assessing depression and apathy during hospitalization, not just at admission, is vital for improving patient outcomes.
