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Effects of UK 69 578: a novel atriopeptidase inhibitor
D B Northridge1, A G Jardine, C T Alabaster
1Department of Cardiology, Western Infirmary, Glasgow.
Lancet (London, England)
|September 9, 1989
Abstract:
UK 69 578 is a competitive inhibitor of endopeptidase 24.11 (the enzyme that degrades atrial natriuretic factor) in vitro. In vivo, UK 69 578 has renal and cardiovascular effects similar to low-dose atrial natriuretic factor infusion, and may be a useful agent in hypertension and heart failure.