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Related Concept Videos

Obesity01:24

Obesity

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

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In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
349
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

419
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
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Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

307
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
307
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

5.9K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
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Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
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Updated: Apr 17, 2026

A Primary Human Trophoblast Model to Study the Effect of Inflammation Associated with Maternal Obesity on Regulation of Autophagy in the Placenta
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A Primary Human Trophoblast Model to Study the Effect of Inflammation Associated with Maternal Obesity on Regulation of Autophagy in the Placenta

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Obesity in pregnancy.

Chu Chin Lim1, Tahir Mahmood1

  • 1Department of Obstetrics and Gynaecology, Victoria Hospital, Kirkcaldy, Fife, UK.

Best Practice & Research. Clinical Obstetrics & Gynaecology
|February 24, 2015
PubMed
Summary

Maternal obesity is a growing global concern, significantly increasing risks for both mothers and their babies during pregnancy and beyond. This condition contributes to maternal mortality and long-term health issues in offspring.

Keywords:
gestational diabetes mellitusobesitypost-partum haemorrhagepre-eclampsiarecurrent miscarriagethromboembolism

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Area of Science:

  • Obstetrics and Gynecology
  • Public Health
  • Maternal-Fetal Medicine

Background:

  • Global obesity prevalence is rising alarmingly in developed and developing nations.
  • Maternal obesity is a significant and increasingly common risk factor in obstetric practice.
  • Obesity was identified as a major risk factor in maternal deaths in the UK (2003-2005).

Purpose of the Study:

  • To highlight the risks associated with maternal obesity.
  • To underscore the impact of maternal obesity on obstetric complications.
  • To inform about the long-term health implications for offspring of obese mothers.

Main Methods:

  • Review of maternal mortality data (e.g., UK Confidential Enquiries).
  • Analysis of obstetric complication rates in relation to maternal weight.
  • Examination of perinatal morbidity and long-term health outcomes in offspring.

Main Results:

  • Over half of women who died from direct or indirect causes were overweight or obese.
  • Maternal obesity elevates risks during antenatal, intrapartum, and postnatal periods.
  • Offspring face higher rates of perinatal morbidity and future health problems.

Conclusions:

  • Maternal obesity poses substantial risks to maternal health and survival.
  • Increased obstetric complications and technical difficulties in fetal assessment are linked to maternal obesity.
  • Addressing maternal obesity is crucial for improving maternal and child health outcomes.