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Updated: Apr 17, 2026
Near Infrared NIr Light Increases Expression of a Marker of Mitochondrial Function in the Mouse Vestibular Sensory Epithelium
Published on: March 14, 2015
Near infrared light mitigates cerebellar pathology in transgenic mouse models of dementia
Sivaraman Purushothuman1, Daniel M Johnstone2, Charith Nandasena2
1Bosch Institute, University of Sydney, NSW 2006, Australia; Discipline of Physiology, University of Sydney, NSW 2006, Australia; Save Sight Institute & Clinical Ophthalmology, University of Sydney & Sydney Eye Hospital, NSW 2000, Australia.
Abstract:
We previously reported that Alzheimer-related pathology in cerebral cortex of APP/PS1 and K3 tau transgenic mouse strains is mitigated by near infrared light (NIr). Here, we extend these observations to the cerebellum. One month of NIr treatment mitigated the deposition of β-amyloid in cerebellar cortex of APP/PS1 mice, and the formation of neurofibrillary tangles, the hyperphosphorylation of tau, the damage caused by oxidative stress and the downregulation of cytochrome oxidase expression by Purkinje cells in the cerebellar cortex of K3 mice. These findings show the ability of NIr to mitigate degeneration in many - probably all - regions of the mouse brain.
