Irritable bowel syndrome: an integrated explanatory model for clinical practice
A P S Hungin1, A Becher1,2, B Cayley3
1School of Medicine, Pharmacy and Health, Durham University, Stockton-on-Tees, UK.
Neurogastroenterology and Motility
|February 24, 2015
Summary
An integrated explanatory model (EM) for Irritable Bowel Syndrome (IBS) was developed from literature. This three-component model addresses gut regulation, brain-gut signaling, and psychological distress for improved IBS diagnosis and patient communication.
Area of Science:
- Gastroenterology
- Psychology
- Medical Communication
Background:
- Irritable Bowel Syndrome (IBS) diagnosis is symptom-based.
- Clinicians face challenges in managing and communicating about IBS due to unclear conceptual understanding.
- A need exists for a clear model to guide clinical practice.
Purpose of the Study:
- To elucidate an integrated explanatory model (EM) for IBS.
- To develop a model from existing literature for practical clinical use.
- To improve conceptual understanding of IBS for clinicians.
Main Methods:
- Systematic literature searches were conducted in PubMed.
- Exploratory searches identified publications on IBS and explanatory models.
- Literature was synthesized to identify key components for an IBS EM.
Main Results:
- No single integrated EM for IBS was found in the literature.
- Three core components for an IBS EM were identified: altered peripheral gut regulation, altered brain-gut signaling, and psychological distress.
- Genetic and epigenetic factors may contribute to IBS etiology and susceptibility.
Conclusions:
- An integrated, three-component EM for IBS was successfully elucidated.
- This model provides a basis for clinicians to conceptualize IBS.
- The model has the potential to enhance IBS diagnosis, management, and patient dialogue.
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