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Phosphatidylinositol4-phosphate 5-kinase prevents the decrease in the HERG potassium current induced by Gq

Taeko Kubo1, Wei-Guang Ding2, Futoshi Toyoda2

  • 1Department of Physiology, Shiga University of Medical Science, Shiga 520-2192, Japan; Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Shiga 520-2192, Japan; Preclinical Research Laboratories, Sumitomo Dainippon Pharma Co., Ltd, Osaka 554-0022, Japan.

Journal of Pharmacological Sciences
|February 24, 2015
PubMed
Summary

Gq protein-coupled receptors reduce human ether-a-go-go-related gene potassium current (IHERG) by decreasing phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). Replenishing PI(4,5)P2 with PI(4)P5-K recovers IHERG function.

Keywords:
ArrhythmiaGq protein-coupled receptorsHERG channelPI(4)P5-KPI(4,5)P(2)

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