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Updated: Apr 17, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Epidemiology of hypertension in CKD
Bruce Horowitz1, Dana Miskulin1, Philip Zager1
1University of New Mexico, Albuquerque, NM; Tufts University, Boston, MA; and Dialysis Clinic, Inc, Nashville, TN.
Insights
Hypertension (HTN) and chronic kidney disease (CKD) are major health issues. Blood pressure control in CKD patients, especially minorities, remains challenging and suboptimal despite improvements.
Area of Science:
- Nephrology
- Cardiology
- Public Health
Background:
- Hypertension (HTN) and chronic kidney disease (CKD) are significant, interconnected global health concerns.
- Approximately 30% of US adults have HTN, and 15% have CKD, with HTN prevalence and control worsening as kidney function declines.
- CKD etiology, albuminuria, genetics, socioeconomic status, and lifestyle all impact HTN severity and prevalence.
Purpose of the Study:
- To review the complex relationship between hypertension and chronic kidney disease.
- To highlight disparities in HTN prevalence, treatment, and outcomes among CKD patients.
- To discuss challenges in blood pressure control for individuals with CKD.
Main Methods:
- Literature review and synthesis of current research on HTN and CKD.
- Analysis of epidemiological data on HTN and CKD prevalence and control.
- Examination of factors influencing HTN severity and treatment resistance in CKD.
Main Results:
- HTN is highly prevalent in CKD patients, often more difficult to control, and treatment can be resistant.
- Racial and ethnic disparities exist in HTN prevalence, BP control, and CKD progression among CKD patients.
- Blood pressure control in Hispanic and African Americans with CKD is notably worse compared to white individuals.
Conclusions:
- Despite improvements, blood pressure control in patients with all stages of CKD remains suboptimal.
- Addressing disparities and improving treatment strategies are crucial for better HTN and CKD management.
- Further research is needed to elucidate optimal blood pressure targets, particularly in hemodialysis patients.
Abstract:
Both hypertension (HTN) and CKD are serious interrelated global public health problems. Nearly 30% and 15% of US adults have HTN and CKD, respectively. Because HTN may cause or result from CKD, HTN prevalence is higher and control more difficult with worse kidney function. Etiology of CKD, presence and degree of albuminuria, and genetic factors all influence HTN severity and prevalence. In addition, socioeconomic and lifestyle factors influence HTN prevalence and control. There are racial and ethnic disparities in the prevalence, treatment, risks, and outcomes of HTN in patients with CKD. Control of blood pressure (BP) in Hispanic and African Americans with CKD is worse than it is whites. There are disparities in the patterns of treatment and rates of progression of CKD in patients with HTN. The presence and severity of CKD increase treatment resistance. HTN is also extremely prevalent in patients receiving hemodialysis, and optimal targets for BP control are being elucidated. Although the awareness, treatment, and control of HTN in CKD patients is improving, control of BP in patients at all stages of CKD remains suboptimal.
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