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Change in aneurysmal flow pulsatility after flow diverter treatment
Ignacio Larrabide1, Arjan J Geers2, Hernán G Morales3
1PLADEMA-CONICET, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Argentina.
Summary
Flow diverters (FDs) significantly alter blood flow dynamics in intracranial aneurysms, increasing pulsatility. This study reveals that FD-induced flow reduction varies throughout the cardiac cycle, impacting treatment efficacy.
Area of Science:
- Biomedical Engineering
- Medical Imaging
- Fluid Dynamics
Background:
- Flow diverters (FDs) are an emerging treatment for intracranial aneurysms.
- Previous research focused on time-averaged or peak systolic flow changes.
- The variability of FD-induced flow reduction during the cardiac cycle remains unexamined.
Purpose of the Study:
- To analyze the cardiac cycle variability of flow reduction induced by flow diverters in intracranial aneurysms.
- To compare time-averaged and peak systolic flow changes post-FD treatment.
Main Methods:
- Virtual treatment of 14 saccular internal carotid artery aneurysms with FDs.
- Computational fluid dynamics (CFD) simulations for pre- and post-treatment blood flow analysis.
- Assessment of hemodynamic variables at each cardiac cycle time step.
Main Results:
- Flow pulsatility significantly increased by 36.0% post-FD treatment.
- Peak systolic velocity reduction (30.5%) was less than time-averaged velocity reduction (43.0%).
- No significant changes in aneurysmal pressure were observed.
Conclusions:
- Flow diverter treatment leads to significant variations in flow reduction throughout the cardiac cycle.
- FDs notably increase intra-aneurysmal flow pulsatility.
