2013 ASCO/CAP updated guidelines for human epidermal growth factor receptor 2 testing: Impact on routine practice
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Updated: Apr 17, 2026

Validated Immunochemical Assay for Comprehensive Determination of the Human Epidermal Growth Factor Receptor 2 Released from and Bound to Cells
Published on: May 9, 2025
Ilaria Pennacchia1, Arnaldo Carbone1, Arcangelo Di Cerbo1
1Institute of Pathology, Catholic University of Sacred Heart, Rome, Italy.
Abstract:
The release of the new ASCO/CAP guideline recommendations for human epidermal growth factor receptor 2 testing has led to clearer descriptive definitions for immunohistochemistry categories. As soon as we started to use them we realized that an increase in the number of ISH test was occurring. Herein we report our lab data obtained by comparing the semester after the release of the new guidelines with the same semester of the previous year. The impact on routine work practice is highlighted.

