Related Experiment Video
Updated: Apr 17, 2026
Modeling The Lifecycle Of Ebola Virus Under Biosafety Level 2 Conditions With Virus-like Particles Containing Tetracistronic Minigenomes
Published on: September 27, 2014
Post-exposure treatment of Ebola virus using passive immunotherapy: proposal for a new strategy
Jean-Philippe Chippaux1, Leslie V Boyer2, Alejandro Alagón3
1UMR 216, Mother and Child Facing Tropical Diseases, Research Institute for Development (IRD), Cotonou, Benin, and School of Pharmacy, Paris Descartes University, Sorbonne Paris Cité, Paris, France ; Institut de Recherche pour le Développement (IRD), 08 BP 841 Cotonou, Bénin.
Background:
Better treatments are urgently needed for the management of Ebola virus epidemics in Equatorial Africa.
Methods:
We conducted a systematic review of the literature on the use of passive immunotherapy for the treatment or prevention of Ebola virus disease. We placed findings from this review into the context of passive immunotherapy currently used for venom-induced disease, and recent improvements in manufacturing of polyvalent antivenom products.
Results:
Passive immunotherapy appears to be one of the most promising specific treatments for Ebola. However, its potential has been incompletely evaluated, considering the overall experience and recent improvement of immunotherapy. Development and use of heterologous serum derivatives could protect people exposed to Ebola viruses with reasonable cost and logistics.
Conclusion:
Hyperimmune equine IgG fragments and purified polyclonal whole IgG deserve further consideration as treatment for exposure to the Ebola virus.
Related Concept Videos
00:42Cross-reactivity
01:31Active versus Passive Immunity
Active Immunity
Active immunity refers to the resistance one develops...