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Retrospective study on osteosarcoma and ewing sarcoma - our experience.

Daniela Nedelcu1, Nicoleta Andreescu1, Estera Boeriu2

  • 1Discipline of Genetics, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.

Maedica
|February 24, 2015
PubMed
Summary
This summary is machine-generated.

This study on bone tumors found delayed diagnosis and advanced stages, particularly in Ewing sarcoma, contributed to lower survival rates. Complications and tumor stage significantly impacted short-term survival in osteosarcoma and Ewing sarcoma patients.

Keywords:
Ewing sarcomabonecancermetastasisosteosarcomatumor

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Area of Science:

  • Oncology
  • Pediatric Oncology
  • Orthopedic Oncology

Background:

  • Primary bone tumors are rare cancers with limited data on their evolution and prognosis.
  • Further research is needed to understand the factors influencing bone tumor progression.

Purpose of the Study:

  • To analyze factors influencing bone tumor evolution in patients with osteosarcoma or Ewing sarcoma.
  • Investigate the impact of lesion site, tumor stage, volume, and complications on patient outcomes.

Main Methods:

  • Retrospective review of a hospital-based registry from 1996-2006.
  • Analysis of 36 pediatric patients (ages 3-23) diagnosed with osteosarcoma or Ewing sarcoma.
  • Evaluation of demographics, lesion site, treatment protocols, and outcomes.

Main Results:

  • Ewing sarcoma (52.94%) was more frequent than osteosarcoma (47.06%).
  • A significant proportion of patients presented with advanced stages (III: 33.3%, IV: 27.7%).
  • Higher incidence of disease-related complications was observed in Ewing sarcoma (51%) compared to osteosarcoma (26.6%).

Conclusions:

  • Five-year survival rates were lower than reported in other studies, potentially due to delayed diagnosis and advanced disease stages.
  • Early diagnosis and stage are critical, especially for Ewing sarcoma, with only 16.66% diagnosed at stages I or II.
  • Short-term survival correlated with symptom onset to diagnosis time, tumor stage, metastasis, and complication severity.