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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
Published on: February 9, 2011
Invasive community-acquired Staphylococcus aureus among pediatric population of Eastern Iran
Mohammadsaeed Sasan1, Nahid Donyadide1, Emran Askari2
1Department of Pediatrics, Mashhad University of Medical Sciences, Mashhad, Iran.
Background And Objective:
Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is increasingly reported worldwide. We aimed to determine the frequency of invasive CA-MRSA in children admitted to the pediatric wards of Imam Reza and Ghaem hospitals of Mashhad, Iran.
Materials And Methods:
In this retrospective study, data regarding S. aureus isolates from pediatric patients' sterile body sites (i.e. blood' joint, bone and lymph node aspiration) were retrieved in a time period from March 2006 to March 2012. Disc diffusion data was analyzed to determine the resistance pattern of the isolates, and differentiation between community-acquired and nosocomial S. aureus was done according to CDC guidelines.
Results:
Twenty three invasive community-acquired S. aureus isolates from sterile body sites were identified, of which seventeen (74%) were CA-MRSA. The CA-MRSA isolates showed high frequency of resistance to non-β-lactam antibiotics (71% to erythromycin' 53% to co-trimoxazole, 44% to gentamicin and 36% to ciprofloxacin).
Conclusion:
In this study, the majority of invasive community-acquired S. aureus isolates were found to be CA-MRSA. Therefore, we recommend that primary treatment should be with antibiotics such as clindamycin, vancomycin, linezolid or daptomycin for any invasive infection suspected to be caused by S. aureus in these two hospitals.
Insights
Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is common in invasive pediatric infections in Iran. Most invasive S. aureus strains were CA-MRSA, necessitating specific antibiotic treatments.
Area of Science:
- Pediatric Infectious Diseases
- Microbiology
- Antimicrobial Resistance
Background:
- Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is a growing global health concern.
- Invasive CA-MRSA infections in children require specific epidemiological investigation.
Purpose of the Study:
- To determine the prevalence of invasive CA-MRSA in pediatric patients admitted to Mashhad, Iran hospitals.
- To analyze the antibiotic resistance patterns of invasive S. aureus isolates.
Main Methods:
- Retrospective analysis of S. aureus isolates from pediatric sterile body sites (March 2006-March 2012).
- Disc diffusion method used for antibiotic susceptibility testing.
- CDC guidelines applied for differentiating community-acquired from nosocomial S. aureus.
Main Results:
- Seventeen out of 23 (74%) invasive community-acquired S. aureus isolates were identified as CA-MRSA.
- CA-MRSA isolates exhibited high resistance rates to erythromycin (71%), co-trimoxazole (53%), gentamicin (44%), and ciprofloxacin (36%).
Conclusions:
- The majority of invasive community-acquired S. aureus infections in this cohort were attributed to CA-MRSA.
- Recommended primary antibiotic choices for suspected invasive S. aureus infections include clindamycin, vancomycin, linezolid, or daptomycin.
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