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Updated: Apr 17, 2026

Experimental Model to Evaluate Resolution of Pneumonia
Published on: February 17, 2023
Organizing Pneumonia Associated with Pegylated Interferon α and Ribavirin Therapy
Amit Chopra1, Creticus Marak2, Narendrakumar Alappan3
1Division of Pulmonary and Critical Care, Albany Medical Center, Albany, NY, USA.
Abstract:
Hepatitis C virus infection is the leading cause of chronic liver disease in the United States of America. Pegylated interferon α and ribavirin combination is the mainstay of treatment. Severe pulmonary toxicities are rarely reported. We report here a case of severe form of organizing pneumonia secondary to pegylated interferon α therapy presenting as acute respiratory failure. Patient has near complete recovery with withdrawal of pegylated interferon α and steroid therapy. We report this case to raise the awareness of this rare but potentially life-threatening pulmonary complication of pegylated interferon α therapy.
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