Related Experiment Video
Updated: Apr 17, 2026

Combined Supine and Standing Imaging for Varicocele: An Improved Diagnostic Approach
Published on: November 22, 2024
Seminoma presenting as renal mass, inferior vena caval thrombus, and regressed testicular mass
Valary T Raup1, Michael H Johnson1, Jonathan R Weese1
1Division of Urologic Surgery, Department of Surgery, Washington University School of Medicine, Saint Louis, MO, USA.
Abstract:
Testicular cancer is the most common malignancy of men aged 15-40. Metastatic spread classically begins with involvement of the retroperitoneal lymph nodes, with metastases to the liver, lung, bone, and brain representing advancing disease. Treatment is based on pathologic analysis of the excised testicle and presence of elevated tumor markers. We report a case of a 34-year-old male presenting with back pain who was found to have a right renal mass with tumor extension into the inferior vena cava. Subsequent biopsy was consistent with seminoma. We review this rare case and discuss the literature regarding its diagnosis and management.
Insights
Testicular cancer, a common malignancy in young men, can rarely present with unusual metastatic patterns. This case highlights a rare presentation of testicular seminoma with renal mass and inferior vena cava involvement.
Area of Science:
- Oncology
- Urology
Background:
- Testicular cancer is the most frequent cancer in men aged 15-40.
- Metastasis typically involves retroperitoneal lymph nodes, progressing to liver, lung, bone, and brain.
- Treatment decisions rely on testicular pathology and tumor marker levels.
Purpose of the Study:
- To report a rare case of testicular seminoma presenting as a renal mass with inferior vena cava extension.
- To review the diagnosis and management of this unusual presentation.
Main Methods:
- Case report of a 34-year-old male with back pain.
- Imaging revealed a right renal mass with tumor extension into the inferior vena cava.
- Biopsy confirmed seminoma.
Main Results:
- The patient presented with back pain, initially suspected as a renal mass.
- Biopsy confirmed the mass as testicular seminoma with unusual metastatic spread.
- This presentation is rare, differing from typical retroperitoneal lymph node involvement.
Conclusions:
- Testicular seminoma can present with rare metastatic patterns, including renal masses and inferior vena cava invasion.
- Early diagnosis and appropriate management are crucial for favorable outcomes.
- Further research into rare presentations of testicular cancer is warranted.
Related Concept Videos
Testes: Histology
The spermatogenic cells, responsible for producing sperm, are...
Disorders of the Male Reproductive System
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Testes: Gross Anatomy
Each testis is surrounded by the tunica albuginea, a dense connective tissue layer that provides structural support and protection. This layer is covered by an outer serous membrane called the tunica vaginalis, which helps reduce friction...
Veins of the Abdomen and Pelvis
The inferior vena cava is fed by numerous smaller veins. The lumbar veins, for instance, drain the posterior abdominal wall, emptying both directly into the inferior vena cava and into the...
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
Infertility in Males

