Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Vascular Contribution to Dementia. World Stroke Organisation Scientific Statement.

International journal of stroke : official journal of the International Stroke Society·2026
Same author

Expansion Revealing of Pathology Resolves Nanostructures Associated with Inflammatory Phenotypes in COVID-19 Decedent Human Brain Tissue.

bioRxiv : the preprint server for biology·2026
Same author

DNA double-strand break signaling induces aberrant neuronal activity.

bioRxiv : the preprint server for biology·2026
Same author

The insulin receptor inhibitor BMS-754807 alleviates neuroinflammation and Alzheimer's disease pathologies across human cellular and mouse models.

Journal of neuroinflammation·2026
Same author

Epigenetically constrained astrocyte states underlie prefrontal cortex vulnerability in Down syndrome-associated Alzheimer's disease.

bioRxiv : the preprint server for biology·2026
Same author

Genetic drivers of progression in Alzheimer's disease are distinct from disease risk.

Alzheimer's research & therapy·2026

Related Experiment Video

Updated: Apr 17, 2026

Quantifying Synapses: an Immunocytochemistry-based Assay to Quantify Synapse Number
18:11

Quantifying Synapses: an Immunocytochemistry-based Assay to Quantify Synapse Number

Published on: November 16, 2010

36.9K

HDAC2 expression in parvalbumin interneurons regulates synaptic plasticity in the mouse visual cortex.

Alexi Nott1, Sukhee Cho1, Jinsoo Seo1

  • 1The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.

Neuroepigenetics
|February 24, 2015
PubMed
Summary

Histone deacetylase 2 (HDAC2) in Parvalbumin (Pv)-interneurons regulates visual cortex critical period closure. Deleting HDAC2 in Pv-interneurons delays closure by reducing inhibition and enhancing synaptic plasticity.

More Related Videos

Longitudinal Two-Photon Imaging of Dorsal Hippocampal CA1 in Live Mice
09:34

Longitudinal Two-Photon Imaging of Dorsal Hippocampal CA1 in Live Mice

Published on: June 19, 2019

17.3K
Vibrodissociation of Neurons from Rodent Brain Slices to Study Synaptic Transmission and Image Presynaptic Terminals
08:38

Vibrodissociation of Neurons from Rodent Brain Slices to Study Synaptic Transmission and Image Presynaptic Terminals

Published on: May 25, 2011

16.1K

Related Experiment Videos

Last Updated: Apr 17, 2026

Quantifying Synapses: an Immunocytochemistry-based Assay to Quantify Synapse Number
18:11

Quantifying Synapses: an Immunocytochemistry-based Assay to Quantify Synapse Number

Published on: November 16, 2010

36.9K
Longitudinal Two-Photon Imaging of Dorsal Hippocampal CA1 in Live Mice
09:34

Longitudinal Two-Photon Imaging of Dorsal Hippocampal CA1 in Live Mice

Published on: June 19, 2019

17.3K
Vibrodissociation of Neurons from Rodent Brain Slices to Study Synaptic Transmission and Image Presynaptic Terminals
08:38

Vibrodissociation of Neurons from Rodent Brain Slices to Study Synaptic Transmission and Image Presynaptic Terminals

Published on: May 25, 2011

16.1K

Area of Science:

  • Neuroscience
  • Epigenetics
  • Developmental Biology

Background:

  • Experience-dependent increases in GABAergic inhibition are crucial for closing critical periods of synaptic plasticity in the visual cortex.
  • Maturation of Parvalbumin (Pv)-expressing interneurons contributes to critical period closure, but the epigenetic role remains unexplored.
  • Histone deacetylase 2 (HDAC2) regulates synaptic plasticity and learning in hippocampal excitatory neurons.

Purpose of the Study:

  • To investigate the role of the epigenetic regulator HDAC2 in Pv-interneurons on cortical inhibition and synaptic plasticity.
  • To determine if HDAC2 in Pv-interneurons influences the closure of the critical period in the visual cortex.

Main Methods:

  • Genetic deletion of HDAC2 specifically in Pv-interneurons of adult mice.
  • Assessment of inhibitory input in the visual cortex.
  • Electrophysiological analysis of long-term depression (LTD) to measure synaptic plasticity.

Main Results:

  • Genetic deletion of HDAC2 in Pv-interneurons reduced inhibitory input in the adult visual cortex.
  • Loss of HDAC2 in Pv-interneurons resulted in enhanced LTD, characteristic of younger animals.
  • These molecular changes correlated with a delayed closure of the visual cortex critical period.

Conclusions:

  • HDAC2 in Pv-interneurons acts as a negative regulator of synaptic plasticity in the adult brain.
  • Loss of HDAC2 in Pv-interneurons delays the closure of the critical period in the visual cortex.
  • Epigenetic mechanisms involving HDAC2 are critical for regulating cortical plasticity and sensory processing maturation.