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Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

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Published on: November 11, 2016

pH-regulated chemical oscillators.

Miklós Orbán¹, Krisztina Kurin-Csörgei¹, Irving R Epstein²

¹†Department of Analytical Chemistry, L. Eötvös University, P.O. Box 32, H-1518 Budapest 112, Hungary.

Accounts of Chemical Research

|February 24, 2015

Summary

This summary is machine-generated.

pH oscillators, systems with periodic pH variation, are crucial in chemistry and biology. Research catalogs these oscillators, categorizes their mechanisms, and explores applications like drug delivery and molecular motors.

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Area of Science:

Chemical Oscillations
Biophysical Chemistry

Background:

Hydrogen ion (pH) plays a critical role in chemistry and biology.
pH oscillators, systems with periodic pH variation, are essential for specific behaviors.
Over two dozen pH oscillators have been discovered since their inception a quarter century ago.

Purpose of the Study:

To present a catalog of known pH oscillators.
To categorize pH oscillators based on their underlying mechanisms.
To explore the applications of pH oscillators in various scientific fields.

Main Methods:

Cataloging and classifying known pH oscillators.
Analyzing mechanistic categories: single oxidant/reductant vs. oxidant/pair of reductants.
Detailed chemical analysis of example systems: hydrogen peroxide-sulfide and ferricyanide-iodate-sulfite.

Main Results:

pH oscillators are divided into two main mechanistic classes.
General mechanisms for each class are described.
Specific examples illustrate the chemistry of each class.

Conclusions:

pH oscillators have diverse applications, including inducing oscillations in other species, pattern formation, and molecular machines.
Developing batch pH oscillators for sustained oscillations in closed systems is a key future goal.
Progress has been made towards achieving long-term batch pH oscillators.