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Updated: Apr 17, 2026

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
Published on: April 24, 2020
Development and validation of a GEANT4 radiation transport code for CT dosimetry
D E Carver1, S D Kost, M J Fernald
1*Department of Radiology and Radiological Sciences, Vanderbilt University, 1161 21st Avenue, Nashville, TN 37232; †Rocky Mountain Oncology Center, 6501 E 2nd St, Casper, WY 82609; ‡Department of Radiology, Ochsner Medical Center, 1514 Jefferson Hwy, New Orleans, LA 70121.
Abstract:
The authors have created a radiation transport code using the GEANT4 Monte Carlo toolkit to simulate pediatric patients undergoing CT examinations. The focus of this paper is to validate their simulation with real-world physical dosimetry measurements using two independent techniques. Exposure measurements were made with a standard 100-mm CT pencil ionization chamber, and absorbed doses were also measured using optically stimulated luminescent (OSL) dosimeters. Measurements were made in air with a standard 16-cm acrylic head phantom and with a standard 32-cm acrylic body phantom. Physical dose measurements determined from the ionization chamber in air for 100 and 120 kVp beam energies were used to derive photon-fluence calibration factors. Both ion chamber and OSL measurement results provide useful comparisons in the validation of the Monte Carlo simulations. It was found that simulated and measured CTDI values were within an overall average of 6% of each other.
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